Did You Know You Can Fight Fat With Peppers?
Scientists from the American Institute of Cancer Research are reporting new evidence that capsaicin, the stuff that gives chili peppers their kick, may cause weight loss and fight fat buildup by triggering certain beneficial protein changes in the body.
Past research suggests that obesity can be reduced by preventing immature fat cells (adipocytes) from developing into mature cells.
Past research also linked capsaicin to a decrease in the amount of fat tissue and decreased blood-fat levels. With that knowledge, the researchers tested capsaicin’s effects on pre-adipocytes and adipocytes growing in laboratory cultures.
They found that capsaicin prevented pre-adipocytes from filling with fat and becoming full-fledged fat cells. The effects occurred at levels just slightly greater than those found in the stomach fluid of an individual eating a typical Indian or Thai diet, the researchers noted. Capsaicin worked by providing a biochemical signal that made fat cells undergo apoptosis, a mechanism in which cells self-destruct.
In the study, rats were fed a high-fat diet, either with or without capsaicin. A comparison group was fed a normal diet, capsaicin-free. Compared to the high-fat eating group, the capsaicin-treated rats showed decreased weight gain and accumulated less fat. The capsaicin-treated animals also gained only slightly more weight than those fed a normal diet.
Analysis found that when the animals were fed a high-fat diet, 37 proteins changed, with many expressing higher levels and others lower. Among these, levels of 20 proteins were partially or fully restored to normal levels in the capsaicin group. The capsulize-treated rats lost 8 percent of their body weight and showed changes in levels of at least 20 key proteins found in fat. The altered proteins work to break down fats.The effected proteins in the capsaicin-treated group are linked with fat and carbohydrate metabolism. “These changes provide valuable new molecular insights into the mechanism of the antiobesity effects of capsaicin,” the scientists say.








